The Berean - Genesis 3:14-15 NASB
(14) The LORD God said to the serpent, "Because you have done this, Cursed are you more than all cattle, And more than every beast of the field; On your belly you will go, And dust you will eat All the days of your life; (15) And I will put enmity Between you and the woman, And between your seed and her seed; He shall bruise you on the head, And you shall bruise him on the heel."
New American Standard Bible
Six thousand years later, the Israelitish people and modern-day Christians living by faith are still anticipating the Promised Seed's second coming in glory. When God gave this judgment, there was little information within the sign to use as an identifier except that Eve was the only female at that time, and she had as yet no children. However, her first child was a son, and the anticipation began. She probably assumed that he was the Promised Seed. She was wrong—he was a murderer.
She had a third son, Seth (Genesis 4:23-25), and he was not the Promised Seed either, but he did become an ancestor of the Promised Seed. The Promised Seed's lineage can be traced from Seth through Noah to Abraham, Jacob, Judah, King David, and finally, Joseph and Mary when He was born in Bethlehem, Judea. The sign took around 4,000 years to come to pass after God's judgment of the Serpent in Genesis 3.
As the centuries slid by, God occasionally added reminders and more precise descriptions of the Promised Seed so that, if the Israelites believed Him, they could more accurately identify the Messiah's appearance when God sent Him. God kept His word. He did send Him, and He performed His responsibility admirably.
— John W. Ritenbaugh